Adverse effects of botulinic toxin on bone and muscle parameters: integrative literature review
DOI:
https://doi.org/10.21270/archi.v10i6.5012Keywords:
Botulinum Toxins, Type A, Bone, Masticatory MusclesAbstract
Introduction: Botulinum toxin type A has been widely used as a therapeutic option for bruxism. However, it is important to discuss its effect on bone and muscle parameters. Objective: To know, through an integrative literature review, the possible adverse effects of therapeutic administration of botulinum toxin on bone and muscle parameters in animal and human models. Method: A search for articles was performed in the Lilacs, PubMed, Scielo and Google Scholar databases, using the terms botulinum toxin and bone and masticatory muscles in the English language and the terms “toxina botulínica e osso e músculos mastigatórios”, in Portuguese. Inclusion of articles in this review followed inclusion and exclusion criteria. Results: 283 articles were found in the databases consulted, 261 articles excluded by title, and no article was excluded by abstract and after their full reading. A total of 22 articles were part of this review. Conclusion: Studies in rats indicate skeletal and muscular changes after BTX-A administration, even with single use, which may result in short and long term bone loss and, thus, potentialize future problems. Further randomized controlled trials should be performed in humans for further clarification on the effects of BTX-A on bone structures.
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