Effectiveness of Antibiotic Prophylaxis in Dental Therapeutics: Systematic Review
DOI:
https://doi.org/10.21270/archi.v11i1.5378Keywords:
Antibiotic Prophylaxis, Dental Clinics, Dental Surgery, DentistryAbstract
Introduction: bacterial involvement is one of the main causes of infections in the head and neck region. For this reason, the therapeutic approach with antimicrobials is recurrent in the field of Dentistry, just as it is quite common to use these drugs as a prophylactic therapeutic mechanism to combat possible systemic infections in the pre and postoperative period. Objective: to evaluate studies on antibiotic prophylaxis in dental surgery clinic. Material and methods: this study consists of an integrative review of the specialized literature on the use of drugs for antibiotic prophylaxis in the scope of dental clinic. For that, the PubMed database was used to search for articles on the topic, using the terms “Antibiotic prophylaxis; Dental clinic; Dental surgery; Dentistry”, limiting studies published between 2010 and 2020. Results and discussion: 784 articles were found and, after applying the eligibility criteria, 17 articles made up the final sample of the review. The results of the articles point to a high adherence to antibiotic prophylaxis in Dentistry. Conclusions: among antimicrobials, amoxicillin alone and combined with potassium clavulanate is effective in preventing post-extraction infection of retained third molars, even though amoxicillin with clavulanate produces more gastrointestinal discomfort.
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Bogacz M, Morawiec T, Smieszek-Wilczewska J, Janowska-Bogacz K, Bubitek-Bogacz A, Roj R, Pinocy K et al. Evaluation of Drug Susceptibility of Microorganisms in Odontogenic Inflammations and Dental Surgery Procedures Performed on an Outpatient Basis Biomed Res Int. 2019:2010453.
Whalen K, Finkel R, Panavelil TA. Farmacologia Ilustrada. 6. ed. Porto Alegre: Artmed; 2016.
Zeng BS, Lin SY, Tu YK, Wu YC, Stubbs B, Liang CS et al. Prevention of Postdental Procedure Bacteremia: A Network Meta-analysis J Dent Res. 2019;98(11):1204-10.
Piltcher OB, Kosugi EM, Sakano E, Mion O, Testa JRG, Romano FR et al. Como evitar o uso inadequado de antibióticos nas infecções de vias aéreas superiores? Posição de um painel de especialistas. Braz J Otorhinolaryngol. 2018;84(3):265-79.
Menon RK, Gopinath D, Li KY, Leung YY, Botelho MG. Does the use of amoxicillin/amoxicillin-clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review with meta-analysis. Int J Oral Maxillofac Surg. 2019;48(2):263-273.
Hafner S, Albittar M, Abdel-Kahaar E, Zolk O. Antibiotic prophylaxis of infective endocarditisin oral and maxillofacial surgery: incomplete implementation of guidelinesin everyday clinical practice. Int J Oral Maxillofac Surg. 2019;49(4):22-8.
Marttila E, Grönholm L, Saloniemi M, Rautemaa-Richardson R. Prevalence of bacteraemia following dental extraction – efficacy of the prophylactic use of amoxicillin and clindamycin, Acta Odontol Scand. 2021;79(1):25-30.
Kashani H, Hilon J, Rasoul MH, Friberg B. Influence of a single preoperative dose of antibiotics on the early implant failure rate. A randomized clinical trial. Clin Implant Dent Relat Res. 2019;21(2):278-83.
Vlcek D, Razavi A, Kutten-Berger J. Antibiotics in third molar surgery. Swiss Dent J. 2014;124(3):294-302.
Thornhill MH, Dayer MJ, Prendergast B, Baddour LM, Jones S, Lockhart PB. Incidence and nature of adverse reactions to antibiotics used as endocarditis prophylaxis. J Antimicrob Chemother 2015;70(8):2382-88.
Sousa ELR, Gomes BPFA, Jaciento RC, Zaia AA, Ferraz CCR. Microbiological profile and antimicrobial susceptibility pattern of infected root canals associated with periapical abscesses. Eur J Clin Microbiol Infect Dis, 2013;32(4):573–580.
Fadare JO, Oshikoya KA, Obimakinde OS, Sijuade AO, Afolayan JM, Adeleke AA et al. Patterns of drugs prescribed for dental outpatients in Nigeria: findings and implications. Acta Odontol Scand. 2017;75(7):496-506.
Posse JL, Fernández MA, Feijoo JF, Henríquez JM, Lockhart PB, Chu VH et al. Intravenous amoxicillin/clavulanate for the prevention of bacteraemia following dental procedures: a randomized clinical trial. J Antimicrob Chemother. 2016;71(7):2022-30.
Iglesias-Martín F, García-Perla-García A, Yañez-Vico R, Aced-Jiménez E, Arjona-Gerveno E, González-Padilla JD et al. Comparative trial between the use of amoxicillin and amoxi- Comparative trial between the use of amoxicillin and amoxi- Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars. Med Oral Patol Oral Cir Bucal. 2014;19(6):e612-5.
Sisalli U, Lalli C, Cerone L, Maida S, Manzoli L, Serra E et al. Amoxicillin and clavulanic acid vs ceftazidime in the surgical extraction of impacted third molar: a comparative study. Int J Immunopathol Pharmacol. 2012;25(3):771-74.
Loyola-Rodriguez JP, Garia-Cortes JO, Martinez-Martinez RE, Patiño-Marin N, Martinez-Castañon GAZavala-Alonso NV. Molecular identification and antibiotic resistant bacteria isolated from primary dentition infections. Aust Dent J. 2014;59(4):497-503.
El-Kholey KE, Wali O, Elkomy A, Almozayen A. Pattern of Antibiotic Prescription for Oral Implant Treatment Among Dentists in Saudi Arabia. Implant Dent. 2018;27(3):317-23.
Shah A, Ramola V, Nautiyal V. Aerobic microbiology and culture sensitivity of head and neck space infection of odontogenic origin. Natl J Maxillofac Surg. 2016;7(1):56-61.
Arteagoitia I, Ramos E, Santamaria G Barbier L, Alvarez J, Santamaria J. Amoxicillin/clavulanic acid 2000/125 mg to prevent complications due to infection following completely bone-impacted lower third molar removal: a clinical trial, Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(1):8-16.
Esen A. The effects of amoxicillin with or without clavulanic acid on the postoperative complaints after third molar surgery: a retrospective chart análisis. J Istanbul Univ Fac Dent. 2017;51(2):1-6.
Loyola-Rodriguez JP, Ponce-Diaz ME, Loyola-Levya A, Garcia-Cortes JO, Medina-Solis CE, Contreras-Ramire AA. Determination and identification of antibiotic-resistant oral streptococci isolated from active dental infections in adults. Acta Odontol Scand. 2018;76(4):229-35.
Sayd S, Vyloppilli S, Kumar K, Subash P, Kumar N, Raseel S. Comparison of the efficacy of amoxicillin-clavulanic acid with metronidazole to azithromycin with metronidazole after surgical removal of impacted lower third molar to prevent infection. J Korean Assoc Oral Maxillofac Surg, 2018;44(3):103-6.
Zanatta FB, Richter EA, Pedroso ARS, Rosing CK. Condutas clínicas na utilização de antibióticos em exodontias. RGO Rev gaúch odontol. 2011;59(2):171-77.
Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M et al. Prevention of infective endocarditis: guidelines from the American Heart Association. J Am Dent Assoc. 2008;139(Suppl):3S-24S.
Oliveira ILM, Ferreira ACA, Mangueira LFB, Farias IAP. Antimicrobianos de uso odontológico: informação para uma boa prática. Odontol Clín.-Cient. 2011;10(3):217-20.
Vasconcelos C, Polônia AJ. Profilaxia antibiotica. Cadernos de Saúde. 2010;3(Esp):101-6.
Schlickmann, A. Profilaxia antibiótica em implantodontia: revisão de literatura [monografia]. Tubarão: Curso de Odontologia, Universidade do Sul de Santa Catarina; 2019.
Ahmad N, Saad N. Effects of antibiotics on dental implants: a review. J Clin Med Res. 2012;4(1):1- 6.
Di Santi BT, Ribeiro MB, Endo MS, Gomes BPFA. Avaliação da suscetibilidade antimicrobiana de bactérias anaeróbias facultativas isoladas de canais radiculares de dentes com insucesso endodôntico frente aos antibióticos de uso sistêmico. Rev Odontol UNESP. 2015;44(4):200-6.
