Erva mate minimiza as alterações do perfil lipídico promovidas por elevado consumo de sacarose
Resumen
A erva mate (Ilex paraguariensis) é composta por bioativos que interferem no metabolismo lipídico. O objetivo foi avaliar se o consumo diário de chá mate (CM) alteraria os depósitos lipídicos e a dislipidemia causada pelo consumo excessivo de sacarose. Trinta ratos Wistar machos (40 dias de idade) foram distribuídos nos seguintes grupos: Grupo C – livre acesso à ração comercial e água deionizada; S – livre acesso à ração comercial, água e solução de sacarose 30% (p/v) em água deionizada e SCM – livre acesso à ração comercial, água, solução de sacarose 30% (p/v) e tratamento com infusão diária de CM (mate solúvel Leão Júnior®) através de sonda orogástrica na dose de 100 mg/Kg/m.c. durante 8 semanas. Após o período experimental o perfil lipídico foi avaliado pelos seguintes parâmetros: pesagem do tecido adiposo retroperitoneal (RETRO) e epididimal (EPI), e dosagem das concentrações plasmáticas de colesterol total, triacilglicerois e HDL-colesterol. O CM promoveu a redução de 1,4 vezes em ambos os tecidos RETRO e EPI no grupo SCM quando comparado ao grupo S. O tratamento com o CM diminuiu 2,7 vezes o triacilglicerois no grupo SCM, quando comparado com o grupo S. O consumo de sacarose não alterou a concentração plasmática de colesterol, entretanto o consumo do CM reduziu de forma significativa o colesterol total circulante. A concentração do HDL-Colesterol, no grupo SCM, mostrou maior concentração em relação ao grupo S (1,3 vezes). O CM previne em ratos machos jovens o aumento dos depósitos lipídicos e a dislipidemia causados pelo consumo excessivo de sacarose.Palavras chave: Sacarose, Ilex paraguariensis, Lipoproteínas HDL; Triglicerídeos; Metabolismo dos Lipídeos; Colesterol.
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Obesidade: Podemos melhorar?. Rev Assoc Med Bras. 2001;47:1-2.
WHO. Obesity and Overweight [Fact sheet]. 2012. Fact sheet N1311. Updated May2012. Retrieved from/http://www.who.int/mediacentre/factsheets/fs311/en/S.
Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA. 2010;303:242-9.
Kanarek RB, Marks-Kaufman R. Developmental aspects of sucrose-induced obesity in rats. Physiol Behav. 1979;23:881-5.
Forschee RA, Storey ML. Total beverage consumption and beverage choices among children and adolescents. Int J Food Sci Nutr. 2003;54:297–307.
Kao YH, Hipakka RA, Liao SE. Modulation of obesity by green tea catechin. Am J Clin Nutri. 2000;72:1232–4.
Shen CL, Chanjaplammootil S, Yeh JK, Cao JJ, Chyu MC, Dagda RY. Anti- obesity and osteo-protective effect of green tea polyphenols on long-term high- fat-diet-induced obesity in rats. FASEB J. 2011;5:776–82.
Chen N, Bezzina R, Lewandowski P A, Caneron S, Mathai ML, Jois M, et al. Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutr Res. 2009; 29:784–93.
Heck CI, Mejla EG. Yerba Mate Tea (Ilex paraguariensis): a comprehensive review on chemistry, health implications, and technological considerations. J Food Sci. 2007; 72:138-51.
Kummer CI, Moura MSG, Almeida RM. Erva Mate. Disponivel em: <http://www.projetos.unijui.edu.br/ modelagem/erva-mate> .Acesso em:27 set. 2013.
Maccari Junior A. Análise do pré-processamento da erva mate para chimarrão. [Tese]. Universidade Estadual de Campinas. 2005.
Pang J, Choi Y.Park, T. Ilex paraguariensis extract ameliorates obesityinduced by high-fat diet: potential role of AMPK in the visceral adipose tissue. Arch Biochem Biophys. 2008;476:178–85.
Arçari DP, Bartchewsky W, Dos Santos TW, Oliveira KA, Funck A, Pedrazzoli J, et al. Antiobesity effects of yerba mate extract (Ilex paraguariensis) inhigh-fat diet-induced obese mice. Obesity. 2009;12:2127–33.
Bracesco N, Sanchez AG, Contreras V, Menini T, Gugliucci A. Recent advances onIlex paraguariensis research: minireview. J Ethnophar-macol. 2011;136:378–84.
Ferreira RF. Inhibition of the passive diffusion of cholic acid by Ilex paraguariensies St. Hil. Saponins. Phytotherapy Res. 1997;11:79-81.
Westerterp-Plantenga MS, Lejeune MP, Kovacs EM. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes Res. 2005;13:1195–204.
Diepvens K, Westerterp KR, Westerterp-Platenga MS. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol. 2007;292:77–85.
Mochizuki M, Hasegawa N. Effects of green tea catechin-induced lipolysis on cytosol glycerol content in differentiated 3T3-L1 cells. Phytother Res. 2004;1: 945-6.
Clifford MN, Ramirez-Martinez JR. Chlorogenic acids and purine alkaloids contents on mate (Ilex paraguariensis) leaf and beverage. Food Chem. 1990; 35:13-21.
Cardozo Junior EL, Ferrarese Filho O, Cardozo Filho L, Ferrarese MLL, Donaduzzi CM, Sturion JA. Methylxanthines and phenolic compounds contents in mate (Ilex paraguariensis) progenies grown in Brazil. J Food Compost Anal. 2007;20:1-10.
Fernandes ES, Machado MO,Becker AM. Andrade F, Maraschin M, Silva EL. Yerba mate (Ilex paraguariensis) enhances the gene modulation and activity of paraoxonase-2: In vitro and in vivo studies. Nutrition. 2012;28:1157-64.
Novelli ELB, Diniz YS, Galhardi CM, Ebaid GMX, Rodrigues hg, Mani F, et al. Anthropometrical parameters and markers of obesity in rats. Lab Anim. 2007:41:111–9.
Schaefer EJ, Gleason JA, Dansinger ML. Dietary fructose and glucose differentially affect lipid and glucose homeostasis. J Nutr. 2009;139:1257–62.
Tsanzi E, Light HR, Tou JC. The effects of feeding sugar-sweetened beverages to growing female Sprague-Dawley rats on bone mass and strength. Bone. 2008;42:960–8.
Boquét N, Campión J, Paternain L, Garcia-Diaz DF, Galarraga MP, Milagro FI, et al. Influence of dietary macronutrient composition on adiposity and cellularity of different fat depots in Wistar rats. J Physiol Biochem. 2009;65:387–95.
Silva RD, Bueno ALS, Gallon CW, Gomes LF, Kaiser S, Pavei C, Ortega GG, Kucharski LC, Jahn MP. The effect of aqueous extract of gross and commercial yerba mate (Ilex paraguariensis) on intra-abdominal and epididymal fat and glucose levels in male Wistar rats. Fitoterapia. 2011; 82:818-26.
George AJ. Central nervous system stimulents. Baillieres Best Pract Res Clin Endocrinol Metab. 2000;13:79-88.
Silveira LR, Alves AA, Denadai BS. Effect of incresed caffeine-induced lipolysis on performance and glucose metabolism during intermittent exercises. Rev bras cienc mov. 2004;12:21-6.
Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J CIin Nutr. 1990;51:759–67.
Hetzler RK, Knowlton RT, Somani SM, Brown DD, Perkins RM. Effect of paraxanthine on FFA mobilization after intravenous caffeine administration in humans. J Appl Physiol. 1990;68:44–7.
Pang J, Choi Y, Park T. Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: potential role of AMPK in the visceral adipose tissue Arch Biochem Biophys. 2008;476:178–85.
Baba N, Bracco EF, Hashim SA. Enhanced thermogenesis and diminished deposition of fat in response to overfeeding with diet containing medium chain triglyceride. Am J CIin Nutr. 1982;35:678–82.
Langfort J, Ploug TJ. Ihlemann. Expression of hormone-sensitive lipase and its regulation by adrenaline in skeletal muscle. Biochem J. 1999; 340:456–9.
Athayde ML, Coelho GC, Schenkel EP. Caffeine and theobromine in epicuticular wax of Ilex paraguariensis A. St-Hil Phytochem. 2000; 55:853–7.
Grant KI, Marais MP, Dhansay MA. Sucrose in a lipid-rich meal amplifies the postprandial excursion of serum and lipoprotein triglyceride and cholesterol concentrations by decreasing triglyceride clearance. Am J Clin Nutr. 1994;59:853-60.
Hudgins LC, Hellerstein MK, Seidman CE, Neese RA, Tremaroli JD, Hirsch J. Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid syntheses in lean and obese subjects. J Lipid Red. 2000;41:595-604.
Faut IM. Role of the fat cell in energy balance physiology. Res Publ Assoc Res Nerv Ment Dis. 1984;62:97-107.
Ikeda I, Hamamoto R, Uzu K, Imaizumi K, Nagao K, Yanagita T. Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats. Biosci Biotechnol Biochem. 2005;69:1049–53.
