Síntesis de un Gel Experimental con Nanopartículas de Plata Sintetizadas Biológicamente utilizadas en la Ruptura de Biopelícula
DOI:
https://doi.org/10.21270/archi.v12i7.5804Palabras clave:
Nanopartículas, Ortodoncía, Plata, Streptococcus mutans, ChitosanaResumen
El objetivo del presente estudio fue sintetizar y evaluar las propiedades biológicas y mecánicas de un gel polimérico asociado a nanopartículas de plata. Los geles estaban compuestos por un complejo biopolímero polielectrolítico Chitosan-Xanthan (CX) asociado o no a nanopartículas de plata (Agnano), los cuales se agruparon en los siguientes grupos: G1) Gel CX; G2) CX Gel + 5% Agnano; G3) CX Gel + 2,5% Agnano; 4) CX Gel + 1,25% Agnano. La caracterización de nanopartículas se realizó mediante análisis dinámico de dispersión de luz, y de geles mediante análisis reológico. La actividad antimicrobiana para Streptococcus mutans se realizó por el método del halo de inhibición. Los resultados obtenidos de DLS mostraron un potencial Zeta de -30 mV y un tamaño de partícula de aproximadamente 100 nm. El análisis reológico muestra que todos los grupos tenían una viscosidad entre 5 y 6,5 Pa, y con el aumento del esfuerzo cortante, la viscosidad de todos los grupos disminuyó. Para el análisis de la actividad antimicrobiana, el potencial antimicrobiano se observó solo para el gel CX que contenía 5% de Agnano. Por lo tanto, se concluye que el gel que contiene 5% de Agnano es prometedor para su uso en pacientes de ortodoncia con una alta tasa de placa bacteriana y puede usarse para prevenir lesiones de manchas blancas durante y después del tratamiento.
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