Eficácia da Insulina Tópica no Manejo de Feridas: Revisão Integrativa da Literatura
DOI:
https://doi.org/10.21270/archi.v15i5.6776Palavras-chave:
Insulina Tópica, Cicatrização, Feridas Crônicas, Feridas Agudas, Revisão IntegrativaResumo
Introdução: A insulina tópica tem se mostrado uma alternativa promissora e de baixo custo no manejo de diferentes tipos de feridas, incluindo úlceras do pé diabético, úlceras venosas, úlceras por pressão, queimaduras e feridas cirúrgicas. Objetivo: Nesse contexto, a presente revisão buscou avaliar evidências clínicas e pré-clínicas acerca da eficácia, segurança e aplicabilidade da insulina tópica no manejo de feridas. Material e Método: Foram avaliados artigos publicados entre 2020 e 2025. Ao todo, 20 estudos foram incluídos a partir das bases PubMed, LILACS e ScienceDirect, envolvendo ensaios clínicos randomizados, estudos quase-experimentais, séries de casos e análises retrospectivas. Resultados: Os achados demonstraram que a insulina tópica acelera a cicatrização, aumenta a formação de tecido de granulação e modula processos inflamatórios, sem eventos adversos relevantes ou risco de hipoglicemia. Apesar da consistência dos resultados, persistem limitações metodológicas, como amostras reduzidas, heterogeneidade de protocolos e curto tempo de seguimento. Conclusão: A insulina tópica representa um adjuvante eficaz e seguro, mas ainda necessita de ensaios multicêntricos, com padronização de doses e formulações, para consolidar sua incorporação nos protocolos clínicos.
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