Large Odontogenic Keratocyst in the Mandible Treated by Surgical Enucleation: Case Report

Authors

  • Vinícius Franzão Ganzaroli DDS, MSc, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil https://orcid.org/0000-0002-8590-4978
  • Laura Vidoto Paludetto DDS, MSc, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil. https://orcid.org/0000-0001-6251-8604
  • Ana Carolina Zucon Bacelar DDS, MSc, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil https://orcid.org/0000-0003-2088-8417
  • Juliana de Aguiar Silveira Meira DDS, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil https://orcid.org/0000-0003-2340-2005
  • Rodrigo Isaias Lopes Pereira DDS, Department of Basic Science, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil https://orcid.org/0009-0004-4234-0692
  • Estêvão Lopes-Pereira DDS, Department of Preventive and Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil https://orcid.org/0000-0002-9766-7519
  • Arthur Nascimento Rocha DDS, Department of Basic Science, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil https://orcid.org/0009-0009-8643-7337
  • Luan Felipe Toro DDS, MSc, PhD, Department of Basic Science, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil https://orcid.org/0000-0002-1049-4257
  • Luciana Estevam Simonato DDS, MSc, PhD, Department of Clinical Propaedeutics and Pathology, Universidade Brasil, Fernandópolis, Brazil https://orcid.org/0000-0002-6413-5479
  • Gestter Willian Lattari Tessarin PhD, General and Applied Biology, Botucatu institute of Biosciences (IBB-UNESP), Brazil https://orcid.org/0000-0001-9448-9289
  • Idelmo Rangel Garcia Júnior DDS, MSc, PhD, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil https://orcid.org/0009-0006-3690-8936
  • Edilson Ervolino DDS, MSc, PhD, Department of Basic Science, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil https://orcid.org/0000-0003-4859-0583

DOI:

https://doi.org/10.21270/archi.v15i1.6744

Keywords:

Odontogenic Cysts, Treatment Outcome, Recurrence, Cone-Beam Computed Tomography

Abstract

Odontogenic keratocyst (OK) is a developmental odontogenic cyst characterized by aggressive clinical behavior, high growth potential, and high recurrence rates, which makes its diagnosis and therapeutic management challenging. The aim of this study was to report and discuss the clinical, radiographic, histopathological characteristics and therapeutic approaches of a case of extensive mandibular OK, initially treated and after recurrence, by enucleation. A 20-year-old female patient was diagnosed with an extensive intraosseous lesion in the posterior region of the right mandible, identified incidentally on radiographic examination. The diagnostic hypothesis of OK was confirmed by histopathological examination after surgical enucleation of the lesion associated with the extraction of the impacted tooth 48. After six months, tomographic examinations showed recurrence, requiring further surgical intervention through enucleation of the recurrent lesion, associated with endodontic treatment of the involved teeth 46 and 47. Clinical and radiographic follow-up after the second surgery showed no signs of recurrence and adequate bone neoformation, confirming the success of the established therapeutic approach. It was possible to conclude that the case reinforces the importance of histopathological diagnosis, careful choice of therapeutic approach, and prolonged clinical and radiographic follow-up, considering the high potential for recurrence of odontogenic keratocyst.

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Published

2026-01-31

How to Cite

Ganzaroli, V. F., Paludetto, L. V., Bacelar, A. C. Z., Meira, J. de A. S., Pereira, R. I. L., Lopes-Pereira, E., … Ervolino, E. (2026). Large Odontogenic Keratocyst in the Mandible Treated by Surgical Enucleation: Case Report. ARCHIVES OF HEALTH INVESTIGATION, 15(1), e6744 . https://doi.org/10.21270/archi.v15i1.6744

Issue

Vol. 15 No. 1 (2026)

Section

Original Articles