Efeito do Tratamento Periodontal sobre o Índice Glicêmico de Pacientes Portadores de Diabete Mellitus: Estudo de Revisão
DOI:
https://doi.org/10.21270/archi.v14i5.6600Palavras-chave:
Diabetes Mellitus, Doenças Periodontais, Saúde Pública, Índice GlicêmicoResumo
O diabetes e a doença periodontal representam importantes problemas de saúde púbica, considerando à alta prevalência e as consequências da progressão das doenças. Estudos sugerem uma relação bidirecional entre os níveis glicêmicos e a condição periodontal, de modo que a inflamação e infecção crônicas presentes na doença periodontal podem ter um efeito adverso no controle glicêmico de pessoas com diabetes, doença que, por sua vez, pode agravar a doença periodontal. Objetivou-se revisar as evidências existentes sobre o efeito do tratamento da doença periodontal sobre o controle glicêmico em adultos. Realizou-se uma busca eletrônica nas bases de dados Cochrane, Embase, Portal Regional da Biblioteca Virtual em Saúde, PubMed, Scientific Electronic Library Online, Scopus e Web of Science. Após aplicação dos critérios de exclusão e inclusão, a qualidade dos artigos foi verificada e a extração de dados foi realizada. Dos 2153 estudos encontrados, 1542 foram removidos por duplicidade, 435 foram eliminados segundo os critérios de exclusão e 16 estudos foram eleitos de acordo com os critérios de inclusão. A maioria dos estudos (n=13; 81.25%) demonstrou evidências de que o tratamento periodontal promove melhora no controle glicêmico. Reforça-se a importância da manutenção da saúde periodontal, considerando o potencial impacto negativo do prejuízo no controle glicêmico sobre a morbidade, mortalidade e qualidade da vida de pacientes com diabetes. Novos estudos qualificados, com integração entre profissionais da área médica e odontológica, devem ser realizados para confirmar esses achados.
Downloads
Referências
anday MZ, Sameer AS, Nissar S. Pathophysiology of diabetes: An overview. Avicenna J Med. 2020;10(4):174-188.
2. American Diabetes Association Professional Practice Committee. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Suppl 1):S17-S38.
3. Gebreyesus HA, Abreha GF, Besherae SD, Abera MA, Weldegerima AH, Gidey AH, et al. Correction: High atherogenic risk concomitant with elevated HbA1c among persons with type 2 diabetes mellitus in North Ethiopia. PLoS One. 2024;19(3):e0300773.
4. Graves DT, Ding Z, Yang Y. The impact of diabetes on periodontal diseases. Periodontol 2000. 2020;82(1):214-224.
5. Preshaw PM, Bissett SM. Periodontitis and diabetes. Br Dent J. 2019;227(7):577-584.
6. Wu CZ, Yuan YH, Liu HH, Li SS, Zhang BW, Chen W, et al. Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health. 2020;20(1):204.
7. Kassebaum NJ, Smith AGC, Bernabé E, Fleming TD, Reynolds AE, Vos T, Murray CJL, Marcenes W; GBD 2015 Oral Health Collaborators. Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990-2015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors. J Dent Res. 2017;96(4):380-387.
8. Costa KL, Taboza ZA, Angelino GB, Silveira VR, Montenegro R Jr, Haas NA, et al. Influence of Periodontal Disease on Changes of Glycated Hemoglobin Levels in Patients With Type 2 Diabetes Mellitus: A Retrospective Cohort Study. J Periodontol. 2017;88(1):17-25.
9. Teshome A, Yitayeh A. The effect of periodontal therapy on glycemic control and fasting plasma glucose level in type 2 diabetic patients: systematic review and meta-analysis. BMC Oral Health. 2016;17(1):31.
10. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I,et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.
11. Jones JA, Miller DR, Wehler CJ, Rich SE, Krall-Kaye EA, McCoy LC, et al. Does periodontal care improve glycemic control? The Department of Veterans Affairs Dental Diabetes Study. J Clin Periodontol. 2007;34(1):46-52.
12. Bharti P, Katagiri S, Nitta H, Nagasawa T, Kobayashi H, Takeuchi Y, et al. Periodontal treatment with topical antibiotics improves glycemic control in association with elevated serum adiponectin in patients with type 2 diabetes mellitus. Obes Res Clin Pract. 2013;7(2):e129-e138.
13. Koromantzos PA, Makrilakis K, Dereka X, Katsilambros N, Vrotsos IA, Madianos PN. A randomized, controlled trial on the effect of non-surgical periodontal therapy in patients with type 2 diabetes. Part I: effect on periodontal status and glycaemic control. J Clin Periodontol. 2011;38(2):142-7.
14. Vergnes JN, Canceill T, Vinel A, Laurencin-Dalicieux S, Maupas-Schwalm F, Blasco-Baqué V et al. The effects of periodontal treatment on diabetic patients: The DIAPERIO randomized controlled trial. J Clin Periodontol. 2018;45(10):1150-1163.
15. Mauri-Obradors E, Merlos A, Estrugo-Devesa A, Jané-Salas E, López-López J, Viñas M. Benefits of non-surgical periodontal treatment in patients with type 2 diabetes mellitus and chronic periodontitis: A randomized controlled trial. J Clin Periodontol. 2018;45(3):345-353.
16. Chen L, Luo G, Xuan D, Wei B, Liu F, Li J, et al. Effects of non-surgical periodontal treatment on clinical response, serum inflammatory parameters, and metabolic control in patients with type 2 diabetes: a randomized study. J Periodontol. 2012;83(4):435-43.
17. Bian Y, Liu C, Fu Z. Application value of combination therapy of periodontal curettage and root planing on moderate-to-severe chronic periodontitis in patients with type 2 diabetes. Head Face Med. 2021;17(1):12.
18. Qureshi A, Bokhari SAH, Haque Z, Baloch AA, Zaheer S. Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial. BMC Oral Health. 2021;21(1):253.
19. Acharya S, Gujjari SK, Murthy S, Battula R. Evaluation of grape seed formulation as an adjunct to scaling and root planing on oxidative stress, inflammatory status and glycaemic control in type 2 diabetic patients with chronic periodontitis: A randomised controlled trial. JCDR. 2021;15(4): ZC20-ZC25.
20. Nishioka S, Maruyama K, Tanigawa T, Miyoshi N, Eguchi E, Nishida W, et al. Effect of non-surgical periodontal therapy on insulin resistance and insulin sensitivity among individuals with borderline diabetes: A randomized controlled trial. J Dent. 2019;85:18-24.
21. Masi S, Orlandi M, Parkar M, Bhowruth D, Kingston I, O'Rourke C, et al. Mitochondrial oxidative stress, endothelial function and metabolic control in patients with type II diabetes and periodontitis: A randomised controlled clinical trial. Int J Cardiol. 2018;271:263-268.
22. Bukleta D, Krasniqi S, Beretta G, Daci A, Nila A, Komoni T, et al. Impact of combined nonsurgical and surgical periodontal treatment in patients with type 2 diabetes mellitus-a preliminary report randomized clinical study. Biomed Res. 2018;29(3):633-639.
23. Kaur PK, Narula SC, Rajput R, K Sharma R, Tewari S. Periodontal and glycemic effects of nonsurgical periodontal therapy in patients with type 2 diabetes stratified by baseline HbA1c. J Oral Sci. 2015;57(3):201-11.
24. Wu Y, Chen L, Wei B, Luo K, Yan F. Effect of non-surgical periodontal treatment on visfatin concentrations in serum and gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus. J Periodontol. 2015;86(6):795-800.
25. Engebretson SP, Hyman LG, Michalowicz BS, Schoenfeld ER, Gelato MC, Hou W, et al. The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. JAMA. 2013;310(23):2523-32.
26. Engebretson SP, Hey-Hadavi J. Sub-antimicrobial doxycycline for periodontitis reduces hemoglobin A1c in subjects with type 2 diabetes: a pilot study. Pharmacol Res. 2011;64(6):624-9.
27. Romito GA, Feres M, Gamonal J, Gomez M, Carvajal P, Pannuti C, et al. Periodontal disease and its impact on general health in Latin America: LAOHA Consensus Meeting Report. Braz Oral Res. 2020;34(supp1 1):e027.
28. Kohnert KD, Heinke P, Vogt L, Salzsieder E. Utility of different glycemic control metrics for optimizing management of diabetes. World J Diabetes. 2015;6(1):17-29.
29. Cavero-Redondo I, Peleteiro B, Álvarez-Bueno C, Rodriguez-Artalejo F, Martínez-Vizcaíno V. Glycated haemoglobin A1c as a risk factor of cardiovascular outcomes and all-cause mortality in diabetic and non-diabetic populations: a systematic review and meta-analysis. BMJ Open. 2017;7(7):e015949.
30. Beutler J, Jentsch HFR, Rodloff AC, Stingu CS. Bacteremia after professional mechanical plaque removal in patients with chronic periodontitis. Oral Dis. 2019;25(4):1185-1194.
31. Martínez-García M, Hernández-Lemus E. Periodontal Inflammation and Systemic Diseases: An Overview. Front Physiol. 2021;12:709438.
32. Fang HSA, Gao Q, Tan WY, Lee ML, Hsu W, Tan NC. The effect of oral diabetes medications on glycated haemoglobin (HbA1c) in Asians in primary care: a retrospective cohort real-world data study. BMC Med. 2022;20(1):22.