Implications of the use of Strontium Ranelate (SRAN) in periodontics, dental implantology, oral surgery, orthodontics and endodontics and its possibility of application as storage media for avulsed teeth
DOI:
https://doi.org/10.21270/archi.v10i9.5255Keywords:
Strontium, Pharmaceutical Preparations, Periodontics, Endodontics, Surgery, Oral, Dental ImplantationAbstract
Dental avulsion is still public health problem and tooth replantation has important unsuccess rates due to root resorption. Strontium ranelate (SRAN) presents antiresorptive property on the bone tissue and stimulates bone formation. So we aimed to comprehensively review the literature to 1- understand the mechanism of action of SRAN regarding to its propaedeutic in periodontics, dental implantology, oral surgery, orthodontics and endodontics, 2- present the current scientific knowledge about the SRAN efficiency on tooth avulsion; 3- observe fails and gaps in the literature and open up for unexplored ideas for SRAN uses and applications. An electronic search was performed crossing the key words ‘strontium ranelate’, ‘periodontics’, ‘dental implantology’, ‘oral surgery’, ‘orthodontics’ and ‘endodontics’, PubMed/Medline, Lilacs and BBO electronic databases were searched for research articles, reviews of literature, animal laboratory studies and laboratory studies, which had been published in English until July 2020. Twenty-five articles fulfilled the inclusion and exclusion criteria. The available literature demonstrates that SRAN provides a really better propaedeutic on the bone tissue and that the topical applications show a lower risk of side effects. That open up new perspectives and for the use of SRAN as a potential storage media for avulsed teeth.
Downloads
References
Azami-Aghdash S, Ebadifard Azar F, Pournaghi Azar F, et al. Prevalence, etiology, and types of dental trauma in children and adolescents: systematic review and meta-analysis. Med J Islam Repub Iran. 2015;29(4):234.
Diangelis AJ, Andreasen JO, Ebeleseder KA, et al. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 1. Fractures and luxations of permanent teeth. Dent Traumatol. 2012;28(1):2-12.
Glendor U. Epidemiology of traumatic dental injuries--a 12 years review of the literature. Dent Traumatol. 2008;24(6):603-11.
Glendor U. Aetiology and risk factors related to traumatic dental injuries--a review of the literature. Dent Traumatol. 2009;25(1):19-31.
Zaleckiene V, Peciuliene V, Brukiene V, Drukteinis S. Traumatic dental injuries: etiology, prevalence and possible outcomes. Stomatologija. 2014;16(1):7-14.
Viegas CM, Scarpelli AC, Carvalho AC, Ferreira FM, Pordeus IA, Paiva SM. Predisposing factors for traumatic dental injuries in Brazilian preschool children. Eur J Paediatr Dent. 2010;11(2):59-65.
Wendt FP, Torriani DD, Assunção MC, Romano AR, Bonow ML, da Costa CT et al. Traumatic dental injuries in primary dentition: epidemiological study among preschool children in South Brazil. Dent Traumatol. 2010; 26(2):168-73.
Moura CC, Soares PB, de Paula Reis MV, Fernandes AJ Neto, Zanetta Barbosa D, Soares CJ. Potential of coconut water and soy milk for use as storage media to preserve the viability of periodontal ligament cells: an in vitro study. Dent Traumatol. 2014;30:22-6.
Veras SRA, Bem JSP, de Almeida ECB, Lins CCDSA. Dental splints: types and time of immobilization post tooth avulsion. J Istanb Univ Fac Dent. 2017;51(3 Suppl 1):S69-S75.
Andersson L, Andreasen JO, Day P, Heithersay G, Trope M, Diangelis AJ et al. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Dent Traumatol. 2012;28:88-96.
Santos ME, Habecost AP, Gomes FV, Weber JB, de Oliveira MG. Parent and caretaker knowledge about avulsion of permanent teeth. Dent Traumatol 2009;25:203-8.
Poi WR, Sonoda CK, Martins CM, Melo ME, Pellizzer EP, de Mendonca MR et al. Storage media for avulsed teeth: a literature review. Braz Dent J. 2013;24:437-45.
Zafar K, Ghafoor R, Khan FR, Hameed MH. Awareness of dentists regarding immediate management of dental avulsion: Knowledge, Attitude, and Practice study. J Pak Med Assoc. 2018;68(4):595-99.
Heydari A, Tahmasbi S, Badiee M, Izadi S, Mashhadi Abbas F, Mokhtari S. The Effect of Root Coating with Titanium on Prevention of Root Resorption in Avulsed Teeth: An Animal Study. Iran Endod J. 2016;11(4):309-14.
Kristerson L, Soder PO, Otteskog P. Transport and storage of human teeth in vitro for autotransplantation and replantation. J Oral Surg. 1976;34:13-8.
Pilmane M, Salma-Ancane K, Loca D, Locs J, Berzina-Cimdina L. Strontium and strontium ranelate: Historical review of some of their functions. Mater Sci Eng C Mater Biol Appl. 2017;78:1222-30.
Marins LM, Napimoga MH, Malta FS, et al. Effects of strontium ranelate on ligature-induced periodontitis in estrogen-deficient and estrogen-sufficient rats. J Periodontal Res. 2020;55(1):141-51.
Yang F, Yang D, Tu J, Zheng Q, Cai L, Wang L. Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling. Stem Cells. 2011;29(6):981-91.
Bakhit A, Kawashima N, Hashimoto K, Noda S. Strontium ranelate promotes odonto-/osteogenic differentiation/mineralization of dental papillae cells in vitro and mineralized tissue formation of the dental pulp in vivo. Sci Rep. 2020;10(1):8375.
Silva GAB, Bertassoli BM, Sousa CA, Albergaria JD, de Paula RS, Jorge EC. Effects of strontium ranelate treatment on osteoblasts cultivated onto scaffolds of trabeculae bovine bone. J Bone Miner Metab. 2018;36(1):73-86.
Scardueli CR, Bizelli-Silveira C, Marcantonio RAC, Marcantonio E Jr, Stavropoulos A, Spin-Neto R. Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies. Int J Implant Dent. 2018;4(1):21.
Rodrigues TA, Freire AO, Bonfim BF, Cartágenes MSS, Garcia JBS. Strontium ranelate as a possible disease-modifying osteoarthritis drug: a systematic review. Braz J Med Biol Res. 2018;51(8):e7440.
Buehler J, Chappuis P, Saffar JL, Tsouderos Y, Vignery A. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone. 2001;29(2):176-79.
Zhao X, Liu Z, Shu D, Xiong Y, He M, Xu S et al. Association of periodontitis with rheumatoid arthritis and the effect of non-surgical periodontal treatment on disease activity in patients with rheumatoid arthritis. Med Sci Monit. 2018;24:5802-10.
Karakan NC, Akpınar A, Göze F, Poyraz Ö. Investigating the Effects of Systemically Administered Strontium Ranelate on Alveolar Bone Loss Histomorphometrically and Histopathologically on Experimental Periodontitis in Rats. J Periodontol. 2017;88(2):e24-e31.
Souza RB, Gomes FIF, Pereira KMA, Dutra PGP, Cunha RMS, Chaves HV et al. Strontium Ranelate elevates expression of heme oxygenase-1 and decreases alveolar bone loss in rats. J Oral Maxillofac Res. 2018;9(4):e4.
Er K, Polat ZA, Ozan F, Taşdemir T, Sezer U, Siso SH. Cytotoxicity analysis of strontium ranelate on cultured human periodontal ligament fibroblasts: a preliminary report. J Formos Med Assoc. 2008;107(8):609-15.
Bizelli-Silveira C, Pullisaar H, Abildtrup LA, Andersen OZ, Spin-Neto R, Foss M et al. Strontium enhances proliferation and osteogenic behavior of periodontal ligament cells in vitro. J Periodontal Res. 2018; 53(6):1020-28.
Wei L, Ke J, Prasadam I, Miron RJ, Lin S, Xiao Y, Chang J et al. A comparative study of Sr-incorporated mesoporous bioactive glass scaffolds for regeneration of osteopenic bone defects. Osteoporos Int. 2014;25(8):2089-96.
Jia X, Miron RJ, Yin C, Xu H, Luo T, Wang J et al. HnRNPL inhibits the osteogenic differentiation of PDLCs stimulated by SrCl 2 through repressing Setd2. J Cell Mol Med. 2019;23(4):2667-77.
Brånemark PI, Adell R, Breine U, Hansson BO, Lindström J, Ohlsson A. Intra-osseous anchorage of dental prostheses. I. Experimental studies. Scand J Plast Reconstr Surg. 1969;3(2):81-100.
Smeets R, Stadlinger B, Schwarz F, et al. Impact of Dental Implant Surface Modifications on Osseointegration. Biomed Res Int. 2016; 2016:6285620.
Park JW, Kim HK, Kim YJ, Jang JH, Song H, Hanawa T. Osteoblast response and osseointegration of a Ti-6Al-4V alloy implant incorporating strontium. Acta Biomater. 2010;6(7):2843-2851.
Zhao L, Wang H, Huo K, Zhang X, Wang W, Zhang Y et al. The osteogenic activity of strontium loaded titania nanotube arrays on titanium substrates. Biomaterials. 2013;34(1): 19-29.
Maïmoun L, Brennan TC, Badoud I, Dubois-Ferriere V, Rizzoli R, Ammann P. Strontium ranelate improves implant osseointegration. Bone. 2010;46(5):1436-41.
Tian A, Zhai JJ, Peng Y, Zhang L, Teng MH, Liao J et al. Osteoblast response to titanium surfaces coated with strontium ranelate-loaded chitosan film. Int J Oral Maxillofac Implants. 2014;29(6):1446-53.
De Bonis A, Uskoković V, Barbaro K, Fadeeva I, Curcio M, Imperatori L et al. Pulsed laser deposition temperature effects on strontium-substituted hydroxyapatite thin films for biomedical implants. Cell Biol Toxicol. 2020;10.1007/s10565-020-09527-3.
Alenezi A, Galli S, Atefyekta S, Andersson M, Wennerberg A. Osseointegration effects of local release of strontium ranelate from implant surfaces in rats. J Mater Sci Mater Med. 2019;30(10):116.
Ozer M, Akdeniz BS, Sumer M. Alveolar ridge expansion-assisted orthodontic space closure in the mandibular posterior region. Korean J Orthod. 2013;43(6):302-310.
Park TK, Vargervik K, Oberoi S. Orthodontic and surgical management of cleidocranial dysplasia. Korean J Orthod. 2013;43(5):248-60.
Zacchetti G, Dayer R, Rizzoli R, Ammann P. Systemic treatment with strontium ranelate accelerates the filling of a bone defect and improves the material level properties of the healing bone. Biomed Res Int. 2014; 2014:549785.
Lavet C, Mabilleau G, Chappard D, Rizzoli R, Ammann P. Strontium ranelate stimulates trabecular bone formation in a rat tibial bone defect healing process. Osteoporos Int. 2017; 28(12):3475-87.
Feldmann I, Bondemark L. Orthodontic anchorage: a systematic review. Angle Orthod. 2006;76(3):493-501.
Currell SD, Liaw A, Blackmore Grant PD, Esterman A, Nimmo A. Orthodontic mechanotherapies and their influence on external root resorption: A systematic review. Am J Orthod Dentofacial Orthop. 2019;155(3): 313-29.
Kirschneck C, Wolf M, Reicheneder C, Wahlmann U, Proff P, Roemer P. Strontium ranelate improved tooth anchorage and reduced root resorption in orthodontic treatment of rats. Eur J Pharmacol. 2014;744:67-75.
Makrygiannakis MA, Kaklamanos EG, Athanasiou AE. Does common prescription medication affect the rate of orthodontic tooth movement? A systematic review. Eur J Orthod. 2018;40(6):649-59.
Zhao S, Wang X, Li N, Chen Y, Su Y, Zhang J. Effects of strontium ranelate on bone formation in the mid-palatal suture after rapid maxillary expansion. Drug Des Devel Ther. 2015;9:2725-34.
Lee BN, Moon JW, Chang HS, Hwang IN, Oh WM, Hwang YC. A review of the regenerative endodontic treatment procedure. Restor Dent Endod. 2015;40(3):179-87.
Huang M, Hill RG, Rawlinson SC. Strontium (Sr) elicits odontogenic differentiation of human dental pulp stem cells (hDPSCs): A therapeutic role for Sr in dentine repair?. Acta Biomater. 2016;38:201-11.
Mizumachi H, Yoshida S, Tomokiyo A, Hasegawa D, Hamano S, Yuda A et al. Calcium-sensing receptor-ERK signaling promotes odontoblastic differentiation of human dental pulp cells. Bone. 2017;101:191-201.
Is Khinda V, Kaur G, S Brar G, Kallar S, Khurana H. Clinical and Practical Implications of Storage Media used for Tooth Avulsion. Int J Clin Pediatr Dent. 2017;10(2):158-65.
Tuna EB, Yaman D, Yamamato S. What is the Best Root Surface Treatment for Avulsed Teeth?. Open Dent J. 2014;8:175-79.
